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10.1002/14651858.CD012990.pub2 [DOI] [PMC free article] [PubMed] [Google Scholar] 66.Chen Y, Zhang Y, Li L, Hlscher C

60 However, in humans, early studies demonstrated that GLP-2 administration for five weeks increased spinal BMD in people with short bowel syndrome, 62 but had limited overall bone benefits

Lixisenatide, approved in 2016, enhances glycemic control in T2DM and has shown tolerable weight reduction but lacks FDA approval for weight management

There are case reports, clinical anecdotes, and small series, but no large, long-term randomized trials specifically testing microdosing schedules

It provides updated recommendations based on a modified Delphi process and supported by a systematic review of the current literature

Specifically in colon cancer and prostate cancer, exendin-4 increased intracellular cAMP levels while inhibiting glycogen synthase kinase 3 and ERK-MAPK activation, leading to an increase in apoptosis [93]