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Description
Most symptoms occur during dose escalation and tend to subside as the body adapts

Sulfonylurea, insulin were stopped first DPP-4 inhibitors early because of cost/benefit GLP-1 and metformin were deprescribed last
While tirzepatide can produce more pronounced weight loss, higher doses may also increase the likelihood of gastrointestinal side effects

Some users may experience reduced appetite and improved blood sugar levels within the first few weeks of starting the medication, while others may take more time, depending on their bodys response to the medication

Patients should be advised to contact their GP promptly or seek urgent care (NHS 111 or A&E) if they experience severe or persistent abdominal pain (which could indicate pancreatitis or gallbladder disease), persistent vomiting, or signs of dehydration

The tablet should be taken on an empty stomach with no more than 4 ounces (120 mL) of plain water, at least 30 minutes before any food, other beverages, or other oral medications
