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They have compared the GLP-1 agonist to bupropion-naltrexone, an older class of weight-loss medication

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However, clinical evidence supporting this combination is limited, and the practice carries potential risks that deserve careful examination before you proceed

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This effect was fully suppressed by the microglial inhibitor minocycline and the p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580, underscoring the essential role of microglial activation and the p38 MAPK pathway [72]