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People report a decreased interest in sex, [similar to their] decreased interest in food when they start semaglutide, says Kohn

But other known side effects of this kind of medication can include variations of the following, according to materials published by the Mayo Clinic, in various severities that vary from patient to patient: Diarrhea Nausea Constipation and other GI issues Bloating Losing weight too quickly comes with its own set of potential side effects and risks, beyond saggy skin

But clinical trial comparisons across different studies carry significant caveats

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Jayedi A, Soltani S, Zargar MS, Khan TA, Shab-Bidar S