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Safety Considerations and Who Should Seek Medical Supervision Compounded tirzepatide is not appropriate for individuals with personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, or severe pancreatitis

If you have recently had a physical exam and lab work and currently visit an internist, there is likely nothing to worry about

However, when used in combination with insulin or sulphonylureas, the risk of hypoglycaemia increases significantly, and dose reductions of these medications may be necessary

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96 , 117 Effects on muscle mass remain to be explored, especially when exercise is combined with the greater weight reduction induced by more effective antiobesity IMDs