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While emerging preclinical research suggests potential anti-inflammatory properties, there is currently no FDA-approved indication for GLP-1 medications in treating Crohn's disease or any inflammatory bowel disease

Metabolism 161:156057 [DOI] [PubMed] [Google Scholar] 19.Scheen AJ (2025) GLP-1 receptor agonists, body composition, skeletal muscle and risk of sarcopaenia: from promising findings in animal models to debated concern in human studies
A 2024 study found that patients taking semaglutide medications were significantly more likely to develop NAION compared to certain other diabetes medications, raising concern about a possible association between GLP-1 drugs and optic nerve injury

10.2337/dc08-1035 40 DeFronzoR
Liraglutide is more like human GLP-1 than exenatide and is injected once daily

Like many of us, you probably hadn't heard of GLP-1 until recently
