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Its heightened expression has been intimately linked to the initiation and severity of diverse autoimmune diseases, spanning rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis (SSc), inflammatory bowel disease, autoimmune diabetes, and even SARS-CoV-2 infection

During the initial weeks of semaglutide therapy and during dose escalations, when gastrointestinal side effects are most pronounced, abstaining from alcohol is advisable

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Nature (1983) 302(5910):7168

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None of the 36 patients taking a placebo achieved all three of these milestones