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Cold sensations have been reported anecdotally by some trial participants, but precise incidence figures are not available from published Phase 2 data

doi: 10.1136/tsaco-2018-000219

Some patients experience persistent gastrointestinal side effects from metformin (bloating, diarrhea) that worsen when combined with semaglutide's appetite-suppressing effects

As a growing cost driver, partially due to successful efforts to increase access and reduce stigma, mental health presents an area of opportunity for addressing health care spending by focusing efforts on appropriateness and quality of care

Similarly, some reviews mention shipping delays or difficulty with order tracking, especially during high-demand periods

A common requirement is having a body mass index (BMI) of 30 or higher