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The primary endpoint will be bodyweight change (week 80 and 104), change in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) in the OA subset, and change in Apnoea-Hypopnea Index (AHI) in the OSA subset

This article explains the trial-based dosing rationale, escalation schedules, influencing factors, side effects, and the current regulatory status in the UK

Plateaus are not treatment failuresthey are expected physiologic responses that rarely require medication discontinuation

Without a clear clinical pathway, GLP-1 usage becomes indefinite and so does the cost

She adds that some long-term clinical trials have also demonstrated that a high protein diet can help protect against weight gain after weight loss, and with no real adverse effects on bone density or kidney function