glp-1/gip agonists Comparing Ozempic, Wegovy and Other GLP-1 Drugs The Sustained Effects of a

By improving the bodys innate capacity to generate insulin in response to elevated blood glucose levels, Ozempic contributes to the maintenance of more stable blood sugar profiles all day

12 Oxidative stress, 13 mitochondrial dysfunction, 14 and endoplasmic reticulum (ER) stress 15 are all involved in NDs induced by brain IR

Endogenous GLP-1 alters postprandial functional connectivity between homeostatic and reward-related brain regions involved in regulation of appetite in healthy lean males: a pilot study

Effects of dapagliflozin on development and progression of kidney disease in patients with type 2 diabetes: an analysis from the DECLARE-TIMI 58 randomised trial

Before the company applied to the FDA for the drug to be approved for obesity, Knudsen and her colleagues 'developed a new methodology to show how [GLP-1] drugs exert their effect on the brain by working on the circumventricular organs and communicating further into the hypothalamus, among other effects.' This was designed to illustrate how GLP-1 worked in 'well- defined neurons in the hypothalamus, in the hindbrain, and in the reward centers.' Their rationale for developing the method was because 'It was very important to show that these medicines work on defined brain circuits and not ones that may be related to psychiatric or cardiovascular side effects, for example' (Nair

Paradoxically, this increase has been associated with improved all-cause mortality as well as cardiovascular mortality, according to a post hoc analysis of the PROactive trial (259)