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In addition, employers reported an increase in the prevalence of cancer and higher utilization of mental health services

Published Phase 2 data shows: Dose Group Discontinuation Due to AE Placebo 0% 1 mg 2.9% 4 mg (escalated) 5.7% 8 mg (escalated) 5.0% 12 mg (escalated) 8.3% For context, discontinuation rates in semaglutide 2.4 mg trials (STEP program) were approximately 7%, and tirzepatide 15 mg trials (SURMOUNT) reported approximately 6-7%

doi: 10.1016/j.molmet.2024.101880 244 Re CecconiADBaroneMFortiMLunardiMCagnottoASalmonaMet al

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Mechanism of Action Each receptor does something different: GLP-1 suppresses appetite and slows digestion, GIP improves insulin sensitivity and fat metabolism, and glucagon increases energy expenditure