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These were "mono-agonists," meaning they targeted only the GLP-1 receptor

These medications mimic the action of a hormone called glucagon-like peptide-1 (GLP-1), which is naturally released after eating to regulate blood sugar and control appetite

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Five out of six tryptophan residues in the N-terminal extracellular domain of the rat GLP-1 receptor are essential for its ability to bind GLP-1

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doi: 10.1677/joe.0.1380159 17 SharmaDVermaSVaidyaSKaliaKTiwariV
