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Methods In accordance with the PRISMA guidelines, we systematically searched PubMed, Embase, Cochrane Library, Web of Science, Scopus, and LILACS for randomized controlled trials and observational studies published between 2000 and 2025

GLP-1 weight loss clinical guide covering semaglutide, tirzepatide, liraglutide dosing protocols, contraindications, and side effect management for medical providers.

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Here, the authors review the physiological roles of GLP-1, the potential renoprotective mechanisms of incretin-based therapies and the available renal outcome data from clinical trials.