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With these data in hand, improved predictive algorithms capable of directly estimating the HLA binding affinity of UAA can be developed, allowing for the direct in silico immunogenicity assessment of UAA-containing peptide and protein therapeutics

The drug is suitable for chronic weight management in patients with: Obesity (body max index equal to or greater than 30), or

This is slightly higher than the typical weight loss experienced by people on Ozempic who dont have diabetes, but less than Wegovy or Saxenda

Furthermore, the subjects enrolled were healthy, lean individuals with no expected effects on pharmacodynamic parameters
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The novel GLP-1/GIP analogue DA5-CH reduces tau phosphorylation and normalizes theta rhythm in the icv
