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In rheumatoid arthritis, our group conducted a retrospective study of patients with RA and overweight or obesity

When assessing WL post-bariatric surgery and WR thereafter before initiation of therapy, our analysis found no significant differences between the GLP-1RAs and placebo groups, with (SMD = 0.23, 95% CI 0.36 to 0.81) for WL and SMD = 0.33, 95% CI 0.11 to 0.77) for WR, respectively (Supplementary Figs

Who Can Benefit from GLP-1 drugs

Retatrutide (Eli Lilly), a triagonist currently in phase III clinical trials (TRIUMPH-1 NCT05929066 and others 3 ) adds a glucagon receptor agonist to its mechanism of action, promising an even greater impact on weight loss

Cardiovascular Effects of Glucagon-like Peptide 1 Receptor Agonists: from Mechanistic Studies in Humans to Clinical Outcomes

Real-world patients also tend to have more lifestyle support, ongoing medical relationships, and gradual dose reductions compared to the abrupt cessation in clinical trials