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As novel incretin therapies are developed, Dr

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Another study also suggested that AgRP neurons within the ARC inhibit the WAT browning effect34)

It raises crucial questions about the sustainability of treatment effects and the practical implications of potentially indefinite therapy

These findings indicated that TGF-1 + IL-1 was sufficient to induce fibroblast activation by activating NLRP3 inflammasome, but insufficient to cause NLRP3/caspase-1/GSDMD-mediated fibroblast pyroptosis, while the underlying mechanism remains to be further explored