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Xing C, Yin Y, Chang R, Gong X, He X, Xie Z (2007) Effects of insulin-like growth factor 1 on synaptic excitability in cultured rat hippocampal neurons

hence, it must be used under medical supervision
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off-label use is rarely covered

The long-standing success and familiarity of these products in the medical community continue to drive the dominance of the parenteral route
However, both trial data and clinical practice suggest that stronger responses are often associated with: Consistent adherence to treatment Ability to tolerate and remain on higher doses Alignment with supportive lifestyle changes It is also likely that individual biology plays a role, although this is not yet fully understood
