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Acknowledgements Thank you to the Director General of Health Malaysia for the permission to publish this paper, and to the International Institute of Rare Sugar Research and Education, Kagawa University for the supervision

While mild cold sensitivity is a common and generally benign experience during treatment with incretin-based medications, certain symptoms warrant medical evaluation to rule out underlying conditions or complications

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After 68 weeks of semaglutide injections, the average patient lost more than 15% of their body weight, but within 12 months of treatment ending, patients regained two thirds of their prior weight loss on average

If the outcome is not favorable, the decision may be able to be appealed

GLP-1 medicines started with injectable GLP-1RAs, then moved to oral peptides, and now co-agonists