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Functional activity of murine intestinal mucosal cells is regulated by the glucagon-like peptide-1 receptor

Ganju and coauthors commented, Defining the role of GLP-1 RAs in Crohns disease is critical as obesity prevalence rises and integrated care models across gastroenterology, endocrinology, and obesity medicine become more essential. This study included 546 patients with CD with overweight or obesity who had initiated use of a GLP-1RA and were matched with 546 nonGLP-1RA users from the TriNetX research network

A pivotal point early on in this research was the use of the known peptide sequence of glucagon to facilitate the discovery of other glucagon-like peptides in the gastrointestinal tract with the help of the radioimmunoassay method ( Figure 1 )

Long-acting GLP-1RAs can also improve the inflammatory response by regulating leptin levels in adipose tissue, which is beneficial for treating obesity-associated diseases [76]

The impact of their molecular mechanisms has been evidenced by landmark trials, which have repeatedly demonstrated that certain GLP-1 RAsincluding liraglutide, semaglutide, and dulaglutideare particularly efficacious in reducing MACE, especially in patients with established ASCVD

Specialist hepatologists may occasionally prescribe off-label in exceptional circumstances, particularly for patients with biopsy-proven NASH and significant fibrosis, but this is not routine practice