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GLP-1 analogs on beta-cells: Glucose dependent insulin secretion For nearly 2 decades now, GLP-1 has been heavily investigated as the most promising therapy target in type 2 diabetes patients

This can make it hard to stick to the medication, even if they know its helping with weight loss

A 2024 study in JAMA Ophthalmology also reported a possible link to a rare eye condition that affects the optic nerve (NAION)

variable absorption due to first-pass metabolism

doi:10.1016/S2213-8587(23)00356-X

Clinical data shows that slower titration improves medication adherence and reduces dropout rates compared to more aggressive dosing schedules