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than older medications, such as metformin
GLP-1RAs also downregulate the expression of MMPs and tissue inhibitors of MPs (TIMPs) for anti-inflammation [110]
As of April 2025, the FDA received over 1,000 adverse event reports related to compounded semaglutide and tirzepatide
p -value 0.1260]), orforglipron (RR 4.9550 [95% CI 0.5427, 45.2367
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107(4): p
