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It means you might need a higher dose, more patience, or a conversation with your provider about whether alternative medications exist for those conditions

Sun chose the former

Intriguingly, in our study, we observed that TIR treatment prevented the HG induced mRNA and protein downregulation of GLUT3 along with GLUT1, GLUT4, and SORBS1, a protein that takes part in diabetes pathogenesis [31], and regulates GLUT4 translocation [32] affecting neuronal insulin resistance [63]
