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Long-term efficacy and safety comparison of liraglutide, glimepiride and placebo, all in combination with metformin in type 2 diabetes: 2-year results from the LEAD-2 study

Retatrutide is Eli Lillys once weekly injectable that targets three pathways at the same time, GLP-1, GIP, and glucagon

However, there is no clear evidence suggesting that the ingredients in the natural GLP-1 patches activate the GLP-1 hormone when delivered transdermally

Given the benefits of rapid diffusion, favorable blood-brain barrier permeability and versatile administration routes, these small molecule compounds will be one of the important candidates of GLP-1RA

GLP-1 medications bind to receptors at sites throughout the body, including the stomach and on appetite and reward centers in the brain

49 LiQ.ZhaoY.GuoH.LiQ.YanC.LiY.et al (2023)