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GLP-1 receptor (GLP-1R) activation Stimulates insulin release and suppresses glucagon secretion Delays gastric emptying Provides central appetite regulation Exhibits biased signaling favoring cAMP over -arrestin recruitment sustained receptor expression and enhanced insulin secretory capacity Benefits include: \Weight Loss: Up to 22.5% reduction in body weight

10.1097/sla.0000000000004457 [DOI] [PubMed] [Google Scholar] Bendotti G., Montefusco L., Lunati M

Table 2 Key characteristics and findings of the major observational studies that evaluated tirzepatide vs

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