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compared with placebo, treatment with GLP-1RA was associated with a 16% and 6% lower risk of MACE in patients with or without preexisting CV disease, respectively (Table 2)

Cortisol naturally peaks in the morning, but chronic stress or irregular routines may disrupt appetite regulation and metabolic health

The impact of rapid weight loss or blood sugar changes on optic nerve health is a key consideration

The Phase 2 NEJM trial (2023) Published in the New England Journal of Medicine under the title "Triple-Hormone-Receptor Agonist Retatrutide for Obesity," this trial (NCT04881760) enrolled 338 adults and ran for 48 weeks

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While less common, some people experience dehydration due to increased urination, which is sometimes seen with GLP-1 receptor agonists like semaglutide