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A patient with a high BMI may meet more than one pathway (for example, BMI 38 with prior stroke meets Tier 1 by BMI alone and Tier 3 by stroke), and that overlap is fine

Available online at: (accessed May, 2026) 26 RibeiroF

doi: 10.1371/journal.pbio.1000355

For the vast majority of patients, the immense, proven systemic benefits of GLP-1 medications, such as reversing severe obesity, stabilizing high blood sugar, reducing the risk of stroke, and preventing kidney failure, far outweigh this rare visual side effect