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Signaling between the gut and the brain involves a complex mix of nutrients, peptides, and microbes that could be targeted as therapies for obesity and diabetes

Methods This systematic review was conducted across PubMed/MEDLINE and Web of Science

![Figure][1] ### Competing Interest Statement The authors have declared no competing interest

GLP-1 receptor agonists like semaglutide can influence sleep patterns through appetite regulation and metabolic changes

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Pharmacovigilance analyses identified disproportionate reporting signals for dyspnoea and asthma-like events, particularly with exenatide, using the reporting odds ratio (ROR 2.14, 95% CI 1.882.43