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Generally well-tolerated in human trials at research doses with no major safety concerns reported [19]

But it is also the most unforgiving

Tirzepatide follows the standard escalation schedule: 2.5 mg weekly for four weeks, increasing to 5 mg, then 7.5 mg, and up to 15 mg weekly depending on weight loss response and gastrointestinal tolerance

In its statement, the MHRA said the treatment is to be used alongside a reduced-calorie diet and increased physical activity

Additionally, manufacturer discounts or patient assistance programs could potentially reduce costs for eligible individuals

The SURMOUNT1 trial included a large study population that was representative of people living with obesity globally