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Second, their pharmacokinetics, efficacy, and relationship between the pharmacokinetics and adverse events are summarized

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Incretin-based therapies, including glucagon-like peptide-1 receptor agonists (GLP-1RAs) and dual glucose-dependent insulinotropicGLP-1RAs, have evolved from metabolic therapies to agents with either proven or potential protective effects on the kidney and heart

Its designation permits its use exclusively for in vitro testing and laboratory experimentation

Several mechanisms may contribute to how GLP-1 RAs reduce body weight

Selective serotonin reuptake inhibitors (SSRIs) : Antidepressants such as fluoxetine or sertraline may help reduce binge frequency, particularly when depression or anxiety co-exists, though they are used off-licence for this indication