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Since they're water-soluble, they're generally well-tolerated, though some people may experience vivid dreams with high doses of B6 or B12 taken later in the day

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When the body loses weight quickly, the skin often cannot shrink at the same pace, leading to sagging, loose skin, and changes in facial structure, especially in the face, neck, and areas where fat was previously stored

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Switching from Shotsy does not mean starting over If you already use Shotsy, the core habits transfer naturally: shot day, dose history, symptoms, weight, and injection-site rotation

However, individuals with pre-existing kidney disease (Stage 2 or worse) should avoid creatine entirely and discuss any supplement use with their prescriber before starting tirzepatide
