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While overall risk of macular degeneration remained low, a study suggests that GLP-1 drugs may have increased that risk in people with diabetes.

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Additionally, several key clinical trial readouts delivered compelling data across multiple indications, for example (see Figure 1): Semaglutide: STEP-HFpEF (functional benefits in HFpEF), STEP-9 (pain reduction in knee osteoarthritis), STEP-10 (reversion to normoglycaemia in pre-diabetic, obese patients), ESSENCE (resolution of MASH, improvement in fibrosis) Tirzepatide: SUMMIT (risk reduction in HFpEF outcomes

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The commercial potential will initially be driven by expansion in the private market, at least while public reimbursement remains constrained

From Montreal to Brooklyn, Los Angeles to Atlanta, little ice cream parlors are drawing big crowds to order, and ogle, the making of the frozen treat.