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Contact your GP if cold sensitivity is severe or persistent, or if accompanied by extreme fatigue, hair loss, unexplained weight gain, breathlessness, or colour changes in hands and feet, as these may indicate thyroid dysfunction, anaemia, or circulatory problems requiring investigation

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Additionally, P9 induces interleukin-6 (IL-6) secretion from the intestine, which subsequently stimulates GLP-1 secretion by intestinal L-cells and pancreatic -cells, and also affects Icam2 mRNA expression, which suggests the normal expression of Icam-2 and the effects of P9 in glucose homeostasis may require IL-6 [160] (Fig