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[DOI] [PubMed] [Google Scholar] 73.Johnson KC, Bray GA, Cheskin LJ, Clark JM, Egan CM, Foreyt JP, et al

Knudsen, J

Investigational oral agents such as orforglipron and danuglipron show promising efficacy in phase II trials for glycemic control and weight reduction, offering flexible dosing and improved adherence [52]

Medical professionals also dont know the potential long-term effects of being on weight-loss drugs for decades, starting in childhood

Patients should be counseled about gastrointestinal side effects and the importance of gradual dose titration

Results In the intention-to-treat analysis, dementia risk was not different between GLP1-RA and DPP4i initiators (hazard ratio [HR] 0.95, 95% confidence interval [CI] 0.871.04