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The medication works by mimicking the effects of incretin hormones, which help regulate blood sugar levels

In many cases, providers may instead recommend selecting the peptide that best aligns with the patients primary goals

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Consistent with this, GIP promotes clearance of circulating TAGs in dogs (168) and enhances adipose tissue TAG accumulation in rats (169) and humans (170)

166 This appears to increase the threshold for muscle fiber action potentials

We compared GLP-1RAs with SGLT2 inhibitors and metformin and found that GLP-1RAs significantly reduced the incidence of major CVEs and mortality rate compared with metformin and second- or third-line glucose-lowering medications