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The research tests a theory that states the human body's GLP-1 pathways function within joint tissues to control joint inflammation that occurs during osteoarthritis and rheumatoid arthritis

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Function The GLP-1 receptor (GLP-1R) is a seven-segmented transmembrane protein with an extracellular amino terminus and an intracellular carboxyl terminus

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Semaglutide typically starts at 0.25 mg weekly, increasing to 0.5 mg, then 1.0 mg, and potentially up to 2.4 mg depending on response and tolerance

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