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A GLP-1 plateau around month 9 isn't failure it's predictable biology

There is a translational gap, however, between animal and human studies on GLP-1RA therapy in modulating IBD activity
Pills are also easier to transport and produce, says Rozalina McCoy, an endocrinologist and internist at the University of Maryland, adding that she hopes the new FDA approval will increase access to the drugs

Both contain the same active ingredient and share similar pharmacokinetics, indications, efficacy, and safety profiles, yet they are prescribed for different conditions
GLP-1 receptors are expressed in reward-related regions, such as the nucleus accumbens (NAc) and ventral tegmental area (VTA), where they influence dopaminergic signaling [43]