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In a rat model of IBS, intraperitoneal administration of exendin-4 normalized stress-induced defecation and visceral pain sensitivity by modulating enteric neuronal function through GLP-1 receptors in submucosal and myenteric ganglion neurons [52]

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Multiple highly effective anti-obesity medications are expensive, and insurers are opting out of coverage of these medications, leading to patients having to stop treatment [63] abruptly