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Moreover, based on the reduction in major cardiovascular events observed with use of GLP-1R agonists in cardiovascular outcome trials in people with type 2 diabetes [89], large-scale outcome trials in overweight and obesity have been initiated (ClinicalTrials.gov registration no
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Compounded versions, particularly of semaglutide and tirzepatide, flooded the market as those drugs were in shortage over the last few years, although tirzepatides shortage was just declared to be resolved