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Having cleared the hurdle as a treatment for diabetes, the FDA then approved semaglutide, marketed as Wegovy, for obesity in 2021, and then in Europe the following year

Ozempic is also approved to help: reduce your risk of certain heart conditions if you have known heart disease and type 2 diabetes prevent the progression of kidney disease and fatal heart problems if you have chronic kidney disease and type 2 diabetes Ozempic contains the active ingredient semaglutide, a glucagon-like peptide-1 receptor (GLP-1) agonist (also called GLP-1 agonists)

Moreover, weight gain and peripheral edema are well-known side effects of TZD, which may limit the role of TZD in the treatment of patients with NAFLD

2-4 Patients may experience facial changes such as dry, dull or sagging skin, a gaunt or hollowed-out facial appearance, or other unwelcome alterations to facial structure and balance

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