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Since the launch of the first GLP-1 RA, exenatide, in 2005, the number of reports has exhibited an overall upward trend, which corresponds with the market launch of subsequent drugs in this class

These factors can shape not only which medications are prescribed, but also whether patients remain on therapy or transition to alternatives

More serious but less common side effects require immediate medical attention

While compounded formulations differ from branded products, the core safety and efficacy data derive from these FDA-reviewed documents

Some compounded formulations match or approach this stability, while others may degrade somewhat faster due to different excipients or preservative concentrations

Bone health deserves attention during rapid weight loss