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Currently under Phase 3 clinical investigation by Eli Lilly, Retatrutide is structurally and mechanistically differentiated from semaglutide, which acts as a single GLP-1 receptor agonist, and tirzepatide, a dual GIP/GLP-1 agonist
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Brunner explained that prescribers often add additional drugs to semaglutide or the tirzepatide to alleviate patient nausea or otherwise help them tolerate the treatment better
