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Interestingly, chronic chemo-genetic stimulation of POA LepR-expressing neurons decreases both food intake and energy expenditure, and results in body weight loss, indicating that the reduced food intake surpasses the decreased energy expenditure [28]

They measure acetoacetate excretion, which decreases as the body becomes more efficient at using ketones

But her symptoms worsened

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On Optical Coherence Tomography (OCT), BLIP appears as a hyperreflective, fusiform thickening within the INL, notably sparing the outer retina and maintaining a preserved ellipsoid zone