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This was a retrospective cohort study of adult patients with a body mass index (BMI)30kg/m2 prescribed GLP-1 analogue therapy at an obesity specialist clinic in Vancouver, Canada

Despite this being prominent in the news, the first medication mentioned by GPs and IMs when asked Which drugs for managing of patients living with obesity are you aware of, even if you have not prescribed them? was, in 54% of responses, the much older and less effective orlistat and its brand names Xenical and Alli (figure 1)

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However, PKA inhibition but not GLP-1R blockade eliminated the protective effects of metformin on endothelial function
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