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Whilst RCTs have reported DKA ranging from 0.84.3% [34], real-world rates of DKA have ranged from 0.0 [38]3.5% [25] with one outlier of 12.5% [14]

Abbreviations ASCVD: Atherosclerotic cardiovascular disease BMI: Body mass index CCI: Charlsons Comorbidity Index CGRD: Chang Gung Research Database CI: Confidence interval CKD: Chronic kidney disease DKA: Diabetic ketoacidosis DKD: Diabetic kidney disease DM: Diabetes mellitus DPP-4is: Dipeptidyl peptidase 4 inhibitors DSCP: Diabetic Shared Care Program eGFR: Estimated glomerular filtration rate EMR: Electronic medical record ESKD: End-stage kidney disease GLP-1RAs: Glucagon-like peptide 1 receptor agonists HbA1c: Glycated hemoglobin HHS: Hyperosmolar hyperglycemic state HR: Hazard ratio ICAM-1: Intercellular adhesion molecules 1 MACEs: Major adverse cardiovascular events MDRD: Modification of diet in renal disease MI: Myocardial infarction NHE3: Sodiumhydrogen exchanger 3 SGLT2is: Sodiumglucose cotransporter 2 inhibitors SHR: Subdistribution hazard ratio STD: Standardized difference TNF: Tumor necrosis factor alpha UACR: Urine albumin-to-creatinine ratio VCAM-1: Vascular cell adhesion protein 1 References Almourani R, Chinnakotla B, Patel R, et al

To evaluate the effect of semaglutide on energy balance and substrate use, DIO mice that received vehicle or semaglutide (9.7 nmol/kg) for 11 days were assessed using indirect calorimetry

Decisions about how quickly or slowly to titrate therapy or restrict calories should be guided by an individual's needs

The most reliable indicator is a sudden change in medication effectiveness

These include potential effects on gallbladder motility and bile composition changes