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A provider may recommend: maintaining a current dose longer before increasing slowing titration if digestive symptoms occur remaining at a lower effective dose adjusting timing of increases pausing increases until tolerance improves Individualized adjustments help support a comfortable and sustainable approach

These impacts should begin to end in 2026 as the new Big Beautiful Bill takes effect

Manufacturer savings or patient assistance programs can further lower copays, making GLP-1 drugs more affordable for patients

After 46 weeks of treatment: 0.6 mg dose: 6.2% mean body weight reduction 2.4 mg dose: 12.5% mean body weight reduction 3.6 mg dose: 13.2% mean body weight reduction 4.8 mg dose: 14.9% mean body weight reduction (all randomized) 4.8 mg dose: 18.7% mean body weight reduction (completers only) Placebo: 2.8% mean body weight reduction Among completers at the 4.8 mg dose, 68.8% achieved at least 10% weight loss, 67% achieved at least 15%, and 40% achieved at least 20% weight loss

Learn more about GLP-1 drugs and oral health from a past episode of the Dental Sound Bites podcast

Who is eligible for GLP-1 weight loss treatment