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The availability of several clinical laboratory variables ensured that PSM generated similar cohorts, emulating the target trial, because matched patients had the same probability of treatment with either drug class

Protein is considered the most satiating macronutrient, with evidence suggesting it suppresses appetite-related hormones such as ghrelin whilst increasing peptide YY, which signals fullness

Neither compound is metabolized through shared enzymatic routes

GLP-1 is involved in regulating blood sugar and digestion

On-and-Off Cycles Many weight-loss specialists now recommend continuous GLP-1 treatment rather than intermittent use because treatment pauses trigger rapid rebound