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They found that these knockout mice showed improvements in aging-related obesity and insulin resistance due to increased thermogenesis
Global Obesity Crisis: Escalating Epidemic Phenomenon Obesity is becoming increasingly prevalent worldwide
Again, extending the time at each dose allows the body more time to adjust

Two larger trials cited within the Langer paper point in the same direction

PMID: 8423228

These data suggest that CSMCs are capable of producing several inflammatory mediators that can play an important role in the pathogenesis of inflammatory conditions of the gastrointestinal system