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There is no reliable predictor for which group a given patient will fall into, though several signals appear in clinical experience: patients with lower baseline BMI, those who reach target weight more easily, and those with stronger behavioural anchors tend to maintain better at reduced doses

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Among those with obesity, GLP-1RA users demonstrated a 47% reduced risk of pancreatic cancer versus insulin users, and a 19% lower risk compared to those taking SGLT2 inhibitors

Any prescription-based option requires independent medical evaluation, screening, and approval through a licensed prescribing provider when appropriate

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