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The mechanism here is multi-factorial: GLP-1R activation reduces hepatic lipogenesis, GIP receptor signalling improves peripheral fat handling, and GCGR activation promotes hepatic fatty acid oxidation directly

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It must be noted that the durations of the completed SURPASS trials were 40 to 52 weeks, although the efficacy and safety of tirzepatide has been shown to be sustained for up to 2 years in 10% of participants in SURPASS-4

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Most healthcare providers individualize duration