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In a large study of over 18,000 patients, those taking tirzepatide lost about 15.3 percent of body weight in one year compared to 8.3 percent with semaglutide

All patients were clinically examined and human body composition (lean mass, fat), weight were measured by bioelectrical impedance analysis InBody 370

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Glucagon has a reputation as the hormone that raises blood sugar, which sounds like the last thing you would want in a weight loss drug

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These hypotheses remain speculative, as there is currently insufficient evidence to establish a direct causal relationship between tirzepatide and cold extremities